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Contraindicated (1)pentobarbital decreases levels of vandetanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration with strong CYP3A4 inducers; these medicines lower exposure to vandetanib by approximately 40%.pentobarbital will reduce the extent or outcome of diclofenac by affecting hepatic e